本团队聚焦天然药物，开展生物活性、结构修饰、新型制剂等研究，针对癌症、综合代谢症、炎症、皮肤病、蚊媒传染病等疾病，进行新药品、保健食品、功能美容化妆品和公共卫生产品的开发与转化。

赵登高，博士，副教授，主要从事天然药物的发现、结构修饰和改造以及蛋白降解剂等研究，先后承担多项国家级和省部级项目，以第一或者通讯作者身份发表SCI论文30余篇。

代表论文

（1） Mo, H.; Liu, J.; Yin, T.; Cao, X.; Su, Z.; Zhao, D.-G.*; Ma, Y.-Y.*, Discovery of a Selective and Orally Bioavailable RET Degrader with Effectiveness in Various Mutations. J. Med. Chem. 2025, 68, 2657−2679.

（2） Zhao, D. G.*; Liu, J.; Su, Z.; Zou, W.; Zhou, Q.; Yin, T.; Jiyao, T.; Ma, Y. Y., * Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo. Euro. J. Med. Chem. 2025, 282, 117052.

（3） Mo, H.; Liu, J.; Su, Z.; Zhao, D. G. *; Ma, Y. Y. *; Zhang, K.; Wang, Q.; Fu, C.; Wang, Y.; Chen, M.; Hu, B. *, Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy. Eur J Med Chem 2024, 277, 116765. 2024.8

（4） Mo, H.; Zhang, R.; Chen, Y.; Li, S.; Wang, Y.; Zou, W.; Lin, Q.; Zhao, D.-G. *; Du, Y. *; Zhang, K.; Ma, Y. Y. *, Synthesis and anticancer activity of novel histone deacetylase inhibitors that inhibit autophagy and induce apoptosis. Euro. J. Med. Chem. 2022, 114705.

（5） Zhang, R.; Mo, H.; Ma, Y. Y.; Zhao, D. G. *; Zhang, K.; Zhang, T.; Chen, X.; Zheng, X., Synthesis and structure-activity relationships of 5-phenyloxazole-2-carboxylic acid derivatives as novel inhibitors of tubulin polymerization. Bioorg Med Chem Lett 2021, 40, 127968.

马燕燕，博士，副教授，主要从事天然药物活性成分的提取分离、结构鉴定、药理活性研究以及功能产品的研发，先后承担多项国家级和省部级项目，以第一或者通讯作者身份发表SCI论文20余篇。

代表论文

（1）Xu, D.; Chen, Y.; Cao, X.-X.; Zheng, J.; Wang, Y.; Ma, Y.-Y. *; Zhang, K.; Zhao, D.-G., Anti-inflammatory activity of phenolics from Dianella ensifolia. Phytochem. Lett. 2024, 61, 187-190.

（2）Li, S.; Xu, D.; Jia, J.; Zou, W.; Liu, J.; Wang, Y.; Zhang, K.; Zheng, X.; Ma, Y. Y. *; Zhang, X.; Zhao, D. G., Structure and anti-inflammatory activity of neo-clerodane diterpenoids from Scutellaria barbata. Phytochemistry 2023, 213, 113771.

（3）Li, X.; Xu, Dan.; Liu, J.; Ma, Y.-Y.; * Zhao, D.-G.; * Zhang, K. Anti-inflammatory activity of phenolics from Hypericum japonicum. Phytochem. Lett. 2023, 55, 156-159.

（4）He, X.; Zhang, M.; Li, S. T.; Li, X.; Huang, Q.; Zhang, K.; Zheng, X.; Xu, X. T.; Zhao, D. G.; Ma, Y. Y., Alteration of gut microbiota in high-fat diet-induced obese mice using carnosic acid from rosemary. Food Sci. Nutr. 2022, 10 (7), 2325-2332.

（5）Ma, Y. Y.; Zhao, D. G.; Zhang, R.; He, X.; Li, B. Q.; Zhang, X. Z.; Wang, Z.; Zhang, K. *, Identification of bioactive compounds that contribute to the alpha-glucosidase inhibitory activity of rosemary. Food Funct. 2020, 11 (2), 1692-1701.

盛钊君，博士，副教授。2014年博士毕业于法国巴黎第七大学药物化学专业，2017年和2023年先后两次在英国利物浦热带医学院访学。目前主要从事植物来源的蚊虫驱避、诱引、灭杀活性成分的筛选、机理研究及缓释剂型开发，主持20余项各类科研项目，以第一或者通讯作者身份在SCI期刊上发表论文16篇。

代表论文

（1）Siyuan Ge, Rongchao Jian, Qiwei Xuan, Yingxiang Zhu, Xiaofei Ren, Wenjiao Li, Xiaole Chen, Ruikang Huang, Chi-Sing Lee, Suet. Leung, Nicoletta Basilico, Silvia Parapini, Donatella Taramelli, Nattapon Pinthong, Svetlana V. Antonyuk, Paul M. O’Neill, Zhaojun Sheng*, W. David Hong*. Novel antimalarial 3-substituted quinolones isosteres with improved pharmacokinetic properties. European Journal of Medicinal Chemistry, 2025, 284, 117228. DOI: 10.1016/j.ejmech.2024.117228

（2）Yuling Li, Jialun Zou, Xiaofei Ren, Wenjiao Li, Weifeng Wu, Qiwei Xuan, Hanwen Miao, Yajie Chen, Chi-Sing Lee, Zhaojun Sheng*. Discovery of α-hexyl cinnamaldehyde and its derivatives as novel larvicides against Aedes albopictus. Arabian Journal of Chemistry, 2024, 17 (9), 105873. DOI: 10.1016/j.arabjc.2024.105873

（3）Yuling Li, Weifeng Wu, Rongchao Jian, Xiaofei Ren, Xiaole Chen, Weiqian David Hong, Min Wu, Jinglin Cai, Canyao Lao, Ximing Xu, Zhaojun Sheng*. Larvicidal, acetylcholinesterase inhibitory activities of four essential oils and their constituents against Aedes albopictus, and nanoemulsion preparation, Journal of Pest Science, 2023, 96: 961-971. DOI: 10.1007/s10340-022-01555-8

（4）Weifeng Wu, Yu Yang, Yingmiao Feng, Xiaofei Ren, Yuling Li, Wenjiao Li, Jietong Huang, Lingjia Kong, Xiaole Chen, Zhongze Lin, Xiaohui Hou, Longlai Zhang, Yajie Chen, Zhaojun Sheng*, Weiqian Hong*. Study of the repellent activity of 60 essential oils and their main constituents against Aedes albopictus, and nano-formulation development, Insects, 2022, 13, 1077. DOI: 10.3390/insects13121077

（5）Zhaojun Sheng, Rongchao Jian, Fangying Xie, Bin Chen, Kun Zhang, Dongli Li, Wenhua Chen, Chiguang Huang, Yan Zhang, Litao Hu, Denggao Zhao, Xi Zheng, Panpan Wu*, Weiqian David Hong. Screening of larvicidal activity of 53 essential oils and their synergistic effect for the improvement of deltamethrin efficacy against Aedes albopictus, Industrial Crops and Products, 2020, 145, 112131. DOI: 10.1016/j.indcrop.2020.112131

陈静，博士，讲师，主要从事抗肿瘤药物的靶向递送、新型纳米材料研究及纳米给药系统在肿瘤靶向免疫治疗中的应用。先后承担多项科研项目，以第一或者通讯作者身份发表SCI论文10余篇。

代表论文

（1）Yuan Lin, Chuangnan Li, Kaijie Cen, Jucai Xu, Jing Chen. Fabrication, characterization, and in vitro biological evaluation of glycyrrhetinic acid ligand-functionalized proliposomes encapsulated docetaxel for treatment of hepatocellular carcinoma. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2025, 707, 135802. (本人为通讯作者）

（2）Liuping Chen, Zhijun Chen, Guo Sien, Haifeng Yang, Yanjiao Liu, Xiaoling Chen, Huiqi Chen, Xinming Chen, Tingting Du, Xinyao Long, Jiaxiong Zhao, Mingli Guo, Lei Wang, Jing Chen, Chunping Liu. Psoriasis Comorbid with Atherosclerosis meets in Lipid Metabolism. Frontiers in Pharmacology, 2023, 12 (10)，105131-151142 （本人为共同通讯作者）

（3）Yuan Lin, Yimin Zhang, Zhuang Xiong, Mi Wu, Muling Zeng, Chuangnan Li, Fujin Liu, Yazhi Liao, Chunping Liu, Jing Chen. Development of glycyrrhetinic acid ligand-functionalized liposomes for targeting hepatocellular carcinoma: Synthesis, preparation, characterization, and evaluation. Arabian Journal of Chemistry, 2023, 16, 105131-105142. （本人为通讯作者）

（4）Jing Chen, Yuan Lin, Min Wu, Chuangnan Li, Kaijie Cen, Fujin Liu, Yazhi Liao, Xiaoqing Zhou, Jucai Xu, Yi Cheng. Glycyrrhetinic acid proliposomes mediated by mannosylated ligand: Preparation, physicochemical characterization, environmental stability and bioactivity evaluation, Colloids and Surfaces B: Biointerfaces, 2022, 218, 112781-112790.（本人为一作及通讯作者）

（5）Chunping Liu, Jing Chen, Huiqi Chen, Tong Zhang, Dongyue He, Qiyuan Luo, Jiaxin Chi, Zebin Hong, Yizhong Liao, Shihui Zhang, Qizhe Wu, Huan Cen, Guangzhong Chen, Jinxin Li, Lei Wang. PCSK9 Inhibition: From Current Advances to Evolving Future. Cells, 2022, 11, 2972-2999. （本人为共同第一作者）

（6）Rongchao Jian, Yuan Lin, Yuling Li, Weifeng Wu, Xiaofei Ren, Zhanyuan Liang, Lingjia Cai, Canyao Lao, Min Wu, Wenhua Chen, Jing Chen, Weiqian David Hong, Zhaojun Sheng. Larvicidal activity of two Rutaceae plant essential oils and their constituents against Aedes albopictus in multiple formulations, Journal of Medical Entomology, 2022, 59(5), 1669-1677.（本人为共同通讯作者）

（7）Yuan Lin, Xin Kang Li, Jia Ying Yan, Ying Lin Lei, Jing Chen, Bao Qiong Li. EEFM combined with N-PLS method for the quantitative determination of psoralen in cosmetics. Chemical Papers, 2022, 76: 5819-5825.（本人为共同通讯作者）

（8） Jing Chen, Yuan Lin, Min Wu, Chuangnan Li, Yimin Zhang, Dongpeng Chen, Yi Cheng. Drug-Free Liposomes Containing Mannosylated Ligand for Liver-Targeting: Synthetic Optimization, Liposomal Preparation, and Bioactivity Evaluation, Journal of Biomedical nanotechnology, 2021, 17(12): 2455-2465.（本人为一作并通讯）