基本情况

陈国栋，研究员，博士生导师，入选广东省教育厅珠江学者特聘教授、广东省自然科学基金杰出青年、广州市珠江科技新星，长期以中药及植物内生真菌作为研究对象，开展中药物质基础、候选药物分子发现以及污染中药材真菌毒素研究。

目前以第一/共同第一或共同通讯作者身份发表SCI论文39篇，包括Nat Comm、Acta Pharm Sin B、Org Lett、Chem Comm 等top期刊8篇，申请授权发明专利13个，其中3个为国外专利。现担任广东省药学学会药物手性专业委员会副主任委员、中国菌物学会菌物化学专委会委员以及《Chinese Chemical Letters》青年编委会委员。同时不断落实教书育人立德树人根本任务，主持项1项广东省高等教育教学改革项目并在担任教工党支部书记期间，以“一核心两强化三融合”开展“锤炼党性，涵养师德”党建工作，入选教育部首届全国高校“双带头人”教师党支部书记工作室、教育部全国党建工作样板支部和广东省党建工作样板支部。

联系方式

地址：广东省江门市蓬江区东成村22号 五邑大学药学与食品工程学院

邮编：529020

邮箱：chgdtong@163.com

近五年主持的科研项目

1. 国家自然科学基金面上基金项目(81973213) “基于活泼中间体驱动策略的苔色酸二聚体多样库构建及其神经保护的构效和机制研究” (2020-2023，56万元，在研)。

2. 国家自然科学基金面上基金项目(81673315) “基于多靶点抗阿尔茨海默症的多节孢绿胶霉素类化合物的优选与作用机制研究” (2017-2020，52万元，在研)。

3. 国家重点研发计划项目(2018YFC0311003) “海洋微生物候选药物的高效发现与创制”项目子课题 (2018-2021，27.8万元，在研)。

4. 广东省自然科学杰出青年基金项目(2017A03036027) “地衣内生真菌中抗老年痴呆活性成分的发现及其作用机制研究” (2017-2021, 100万元，在研)。

广州市珠江科技新星项目(201610010021) “地衣内生真菌中抗AD活性成分研究” (2016-2019, 30万元，结题)。

近五年发表代表性论文

[1] Huang Hui-Yun, Huang Jia-Hua, Wang Yong-Heng, Hu Dan, Lu Yong-Jun, She Zhi-Gang, Chen Guo-Dong^*, Yao Xin-Sheng, Gao Hao^*. The oxidation cascade of a rare multifunctional P450 enzyme involved in asperterpenoid A biosynthesis. Frontiers in Chemistry, 2021, 9, 785431.

[2] Zhao Huan, ^§ Zou Jian, ^§ Xu Wei, Hu Dan, Guo Liang-Dong, Chen Jia-Xu, Chen Guo-Dong,* So Kwok-Fai, Yao Xin-Sheng, Gao Hao.* Diisoprenyl-cyclohexene/ane-type meroterpenoids from Biscogniauxia sp. and their anti-inflammatory activities. Journal of Organic Chemistry, 2021, 86, 11177-11188.

[3] Chen Guo-Dong,^§ Zhao Bing-Xin,^§ Huang Mei-Juan, Tang Jia, Li Yan-Bing, Guo Liang-Dong, He Rong-Rong, Hu Dan,* Yao Xin-Sheng, Gao Hao.* Tripodalsporormielones A–C, unprecedented cage-like polyketides with complex polyvdent bridged and fused ring systems. Acta Pharmaceutica Sinica B, 2021, 11, 3648-3654.

[4] Tian Dan-Mei, Cao Ling-Yun, Li Qing-Wen, Huang Hui-Yun, Xu Wei, Chen Guo-Dong*, Song Zhao-Hui, He Yi, Yao Xin-Sheng, Tang Jin-Shan*. Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica pubescens. Bioorganic Chemistry, 2021, 107, 104604.

[5] Chen Guo-Dong, Hu Dan, Gao Hao, Yao Xin-Sheng*. The importance of researches on the fungal bioactive secondary metabolites in developing the comprehensive health industry. Chinese Journal of Natural Medicines, 2020, 18, 241-242.

[6] Chen Guo-Dong^§, Hu Dan^§, Huang Mei-Juan^§, Tang Jia, Wang Xiao-Xia, Zou Jian, Xie Jun, Zhang Wei-Guang, Guo Liang-Dong, Yao Xin-Sheng*, Abe Ikuro*, Gao Hao*. Sporormielones A–E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin. Chemical Communications, 2020, 56, 4607-4610. (^§co-first author)

[7] Chen Guo-Dong, Wang Chuan-Xi, Hu Dan, Gao Hao, Yao Xin-Sheng*. Discovery of new metabolites from fungi in special habits and their biological function evaluations. Toxicon, 2019, 158, S29-S29.

[8] Zou Jian^§, Chen Guo-Dong^§, Zhao Huan, Wang Xiao-Xia, Zhang Zai-Jun, Qu Yi-Bo, He Rong-Rong, So Kwok-Fai, Yao Xin-Sheng, Gao Hao*. Triangeliphthalides A-D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism. Chemical Communications, 2019, 55, 6221-6224. (^§co-first author)

[9] Zhao Huan^§, Wang Mei-Zhi^§, Chen Guo-Dong*, Hu Dan, Li En-Qing, Qu Yi-Bo, Zhou Li-Bing, Guo Liang-Dong, Yao Xin-Sheng, Gao Hao*. Dimericbiscognienynes B and C: new diisoprenyl-cyclohexene-type meroterpenoid dimers from Biscogniauxia sp. Chinese Chemical Letters, 2019, 30, 51-54.

[10] Wang Gao-Qian^§, Chen Guo-Dong^§, Qin Sheng-Ying^§, Hu Dan*, Awakawa Takayoshi, Li Shao-Yang, Lv Jian-Ming, Wang Chuan-Xi, Abe Ikuro*, Gao Hao*. Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage. Nature Communications, 2018, 9, 1838 (^§co-first author)

[11] Zou Jian^§, Chen Guo-Dong^§, Zhao Huan, Huang Ying, Luo Xiang, Xu Wei, He Rong-Rong, Hu Dan, Yao Xin-Sheng, Gao Hao*. Triligustilides A and B: Two pairs of phthalide trimers from Angelica sinensis with a complex polycyclic skeleton and their activities. Organic Letters, 2018, 20, 884-887 (^§co-first author)

[12] Li Jiao-Jiao^§, Chen Guo-Dong^§, Fan Hong-Xia, Hu Dan, Zhou Zheng-Qun, Lan Kang-Hua, Zhang Hui-Ping, Maeda Hideaki, Yao Xing-Sheng, Gao Hao*. Houttuynoid M, an anti-HSV active houttuynoid from Houttuynia cordata featuring a bis-houttuynin chain tethered to a flavonoid core. Journal of Natural Products, 2017, 80, 3010-3013 (^§co-first author)

[13] Zhao Huan^§, Chen Guo-Dong^§, Zou Jian, He Rong-Rong, Qin Sheng-Ying, Hu Dan, Li Guo-Qiang, Guo Liang-Dong, Yao Xin-Sheng*, Gao Hao*. Dimericbiscognienyne A: A meroterpenoid dimer from Biscogniauxia sp. with new skeleton and its activity. Organic Letters, 2017, 19, 38-41 (^§co-first author)

[14] Sun Tian-Yu, Zou Jian, Chen Guo-Dong*, Hu Dan, Wu Bin, Liu Xing-Zhong, Yao Xin-Sheng, Gao Hao*. A set of interesting sequoiatone stereoisomers from a wetland soil-derived fungus Talaromyces flavus. Acta Pharmaceutica Sinica B, 2017, 7, 167-172.

[15] Wang Chuan-Xi^§, Chen Guo-Dong^§, Feng Chun-Chi, He Rong-Rong, Qin Sheng-Ying, Hu Dan, Chen He-Ru, Liu Xing-Zhong, Yao Xin-Sheng*, Gao, Hao*. Same data, different structures: diastereoisomers with substantially identical NMR data from nature. Chemical Communications, 2016, 52, 1250-1253 (^§co-first author)

申请专利

[1] 姚新生，洪葵，李佳，高昊，唐金山，林海鹏，高立信，陈国栋，谢晴宜，盛丽. 一种芳香类化合物作为制备Caspase 3 抑制剂的用途. (ZL 201010230402.2)

[2] 高昊，姚新生，郑易之，郭良栋，陈国栋，孙翔，郑启昌，孔明珠，李小霞. 脱甲绿胶酶素在制备β-淀粉样蛋白聚集抑制剂中的用途. (201310196180.0)

[3] 高昊，姚新生，郑易之，陈国栋，郭良栋，孙翔，赵欢，李小霞，孔明珠. 联苯醚类化合物在制备β-淀粉样蛋白聚集抑制剂中的用途. (ZL201410332005.4)

[4] 高昊，陈国栋，姚新生，郭良栋，胡丹，于洋，赵琴，冯晓琳，李小霞，王高乾. 裂环多节孢绿胶霉素类化合物及其用途. (ZL201510111322.8)

[5] 高昊，陈国栋，姚新生，郭良栋，胡丹，于洋，赵琴，冯晓琳，李小霞，王高乾. 多节孢绿胶霉素E及其用途. (ZL 201510112075.3)

[6] 高昊，陈国栋，姚新生，郭良栋，胡丹，于洋，赵琴，冯晓琳，李小霞，王高乾. 多节孢绿胶霉素类化合物及其用途. (ZL 201510112090.8)

[7] 高昊，陈国栋，姚新生，赵欢，郭良栋，胡丹，王传喜，秦盛莹，邹剑. 二聚炭皮烯炔A及其在制备预防和治疗神经退行性疾病药物中的应用. (ZL201611101694.3)

[8] 高昊，陈国栋，姚新生，赵欢，郭良栋，胡丹，王传喜，秦盛莹，邹剑. 炭皮酸A及其在制备预防和治疗神经退行性疾病药物中的应用. (ZL201611101594.0)

[9] 高昊，姚新生，何蓉蓉，李药兰，陈国栋，周正群，王传喜，李满妹，胡丹，范红霞. 一种二咖啡酰亚精胺衍生物糖苷及其用途. (ZL201610032769.0、PCT/CN2017/071119)

[10] 高昊，姚新生，何蓉蓉，陈国栋，周正群，王传喜，胡丹，范红霞. 一种二咖啡酰亚精胺环化衍生物及其用途. (ZL201610033609.8、PCT/CN2017/071116)

[11] 高昊，胡丹，陈国栋，姚新生，秦盛莹，王高乾，吕建明，李韶阳. 甾体化合物侧链修饰基因及其应用. (ZL201810335957.X)

[12] 陈国栋、赵欢、胡丹、王传喜、代萍、刘妍颖、高昊、姚新生. 一种炭皮苯酞类化合物、组合物、制备方法及其用途. (ZL 201910418547.6)

[13] 胡丹、韩雪、王传喜、高昊、姚新生、陈国栋、代萍、张洁. 一种吲哚二萜生物碱类化合物、组合物及其制备方法和用途. (ZL 201910495789.5)

[14] 高昊、陈国栋、姚新生、胡丹、代萍、唐佳、黄美娟.荚孢腔酮类化合物及其制备方法和用途. (ZL202010165727.0)

[15] 陈国栋、高昊、胡丹、姚新生、代萍、黄美娟. 三桥环荚孢腔酮类化合物及其制备方法和用途. (202110390198.9)