基本情况

陈文华，博士，药学与食品工程学院教授，博士生导师，现任五邑大学副校长、五邑大学科协主席等职。兼任广东省药学会药物化学专业委员会副主任委员和广东省药理学会理事等。曾留学日本和美国。研究领域为药物化学生物学，多年来专注于创新药物的设计合成及生物活性机制研究。先后主持国家自然科学基金面上项目等10余项科研项目，在J. Am. Chem. Soc., J. Med. Chem.等顶尖学术刊物上发表SCI论文160余篇，获授权发明专利10余件。2016年获日本兵库震灾纪念21世纪研究机构兵库海外研究网络（Hyogo Overseas Research Network）事业推进奖。入选全球前2%顶尖科学家榜单“终生科学影响力排行榜”科研人员。

联系方式

地址: 广东江门市东成村22号 五邑大学 药学与食品工程学院，邮编529020

E-mail: whchen@wyu.edu.cn

教育经历

1994年 四川大学化学系 化学专业学士学位

2000年 日本长崎大学药学院 药物化学专业博士学位

工作经历

2000年4月-2002年3月，日本科学技术振兴机构 博士研究员

2002年4月-2005年10月，中山大学化学与化学工程学院 副教授

2004年7月-2009年8月，美国里海大学化学系 研究科学家

2009年8月-2018年12月，南方医科大学药学院 教授，博士生导师

2019年1月-2023年11月，五邑大学生物科技与大健康学院 教授，博士生导师

2023年11月-至今，五邑大学药学与食品工程学院 教授，博士生导师

讲授课程

本科生：《药物化学》《实验药物化学》《高等药物化学》《有机结构解析》

研究生：《有机波谱分析》

科研方向

1) 基于离子跨膜转运机制的抗肿瘤药物的设计合成及生物活性

2) 生物重要分子的生物传感器的构筑

科研项目

1) 国家自然科学基金面上项目，氟代阴离子转运体的合成及其诱导细胞死亡机制研究，63万元，2019年01月-2022年12月，主持。

2) 江门市科学技术局创新科研团队引进资助项目(新生物功能分子的发现与开发研究创新团队)，岭南15种药食同源植物活性物质基础和深度开发研究，600万，2019年01月-2021年12月，第二核心成员。

近五年发表的主要论文

(1) Yufei Zhang , Jingjing Liu , Jiangyi Li , Jinping Sun , Bingwen Liang , Xiaofeng Min , Zhuang Xiong^*, Wen-Hua Chen^*, Xuetao Xu^*, Design, synthesis and biological evaluation of a 1,2,3-triazolyl-bearing betulinic acid derivatives as α-glucosidase inhibitors, J. Mol. Struct., 2025, 1328, 141252.

(2) Wantao Liao, Chunzheng Wang, Ruiya Wang, Mengzhao Wu, Lanqing Li^*, Pengjie Chao, Jinhui Hu, Wen-Hua Chen^*, An activatable “AIE + ESIPT” fluorescent probe for dual-imaging of lipid droplets and hydrogen peroxide in drug-induced liver injury model, Anal. Chim. Acta, 2025, 1335, 343442

(3) Jingxin Hu, Ruiya Wang, Wantao Liao, Jinhui Hu, Langing Li^*, Zhen Cheng^*, Wen-Hua Chen^*, A novel donor-acceptor fluorescent probe for the fluorogenic/ chromogenic detection and bioimaging of nitric oxide. Anal. Chim. Acta, 2024, 1296, 342333.

(4) Xiang Qiu, Yanghui Ou, Shengjia Lu, Yibin Liang, Yali Zhang, Mengjie Li, Gang Li, Hongwei Ma, Yanting Wu, Zhaoyu He, Zhensheng Zhang, Hongliang Yao^*, Wen-Hua Chen^*, Study on the structure and bioactivity of polysaccharides from different parts of Stemona tuberosa Lour, Molecules, 2024, 29, 1347.

(5) Yufei Zhang, Jiangyi Li, Xiaofeng Min, Bingwen Liang, Jinping Sun, Keyin Lin, Zhuang Xiong^*, Xuetao Xu^*, Wen-Hua Chen^*, 1,2,3-Triazole-based betulinic acid derivatives as α-glucosidase inhibitors: Synthesis and in vitro and in vivo biological evaluation. J. Mol. Struct., 2024, 1310, 138294.

(6) Yufei Zhang, Xiaoyan Yu, Jiangyi Li, Bingwen Liang, Jinping Sun, Xiaofeng Min, Zhuang Xiong^*, Wen-Hua Chen^*, Xuetao Xu^*, Design, synthesis and biological evaluation of novel betulinic acid derivatives containing 1,2,4-triazole-derived schiff bases as α-glucosidase inhibitors. J. Mol. Struct., 2024, 1315, 138889.

(7) Yuechang Huang^#, Xingmin Zhang^#, Qian Li, Wende Zheng, Panpan Wu, Rihui Wu^*, Wen-Hua Chen^*, Chen Li^*, N-p-Coumaroyloctopamine ameliorates hepatic glucose metabolism and oxidative stress involved in a PI3K/AKT/GSK3ß pathway, Front. Pharmacol., 2024, 15, 1396641.

(8) Hai-Tao Zhi, Zhonghui Lu, Li Chen, Jia-Qiang Wu, Lanqing Li, Jinhui Hu^*, Wen-Hua Chen^*, Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: design, synthesis and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates, Bioorg. Chem., 2024, 147, 107421.

(9) Jifan Cao, Wende Zheng, Baizhong Chen, Zhenping Yan, Xiaowen Tang, Jiahao Li, Zhen Zhang, Song Ang, Chen Li, Rihui Wu, Panpan Wu^*, Wen-Hua Chen^*, Chemical composition of essential oil from Citrus reticulata Blanco cv. Chachiensis (Chachi) and its anti-mosquito activity against Pyrethroid-resistant Aedes albopictus. Insects, 2024, 15, 345.

(10) Zi Li^#, Chengguo Li^#, Baizhong Chen, Bing Li, Gang Huang, Yuhao Huang, Yajun Hou, Pengjun Zhong, Jingwei Jin, Dongli Li, Karl Wah Keung Tsim, Lishe Gan^*, Wen-Hua Chen^*, Rihui Wu^*, Parabacteroides goldsteinii enriched by Pericarpium Citri Reticulatae ‘Chachiensis’ polysaccharides improves colitis via the inhibition of lipopolysaccharide-involved PI3K-Akt signaling pathway, Int. J. Biol. Macromol., 2024, 277, 133726.

(11) Lanqing Li^*, Chunzheng Wang, Jinhui Hu^*, Wen-Hua Chen^*, Recent progresses in organelle-targeting fluorescent probes for the detection of peroxynitrite, Chem. Commun., 2024, 60, 13629 - 13640.

(12) Wei Lin, Yifei Qu, Huixuan Zhu, Mei Xie, Jinhui Hu, Zhuang Xiong, Wen-Hua Chen^*, Jun Xu^* and Jia-Qiang Wu^*, Rh(III)-catalyzed, redox-neutral, C–H multifluoro- alkenylation of benzamides, Synthesis, 2024, 56, 3045 - 3053.

(13) Xiang Qiu^#, Yan Geng^#, Xiaoyue Cai, Yanghui Ou, Mengjie Li, Yali Zhang, Dengqin He, Xudong Qian, Yanting Wu, Hongwei Ma, Jing-Kun Yan*, Hongliang Yao^* and Wen-Hua Chen^*, Anti-inflammatory activity and underlying mechanism against sepsis-induced acute lung injury of a low-molecular-weight polysaccharide from the root of Stemona tuberosa Lour. Int. J. Biol. Macromol., 2024, 282, 136617.

(14) Yifei Qu^#, Xiaojia Cai^#, Yuzhuang Guan^#, Jiamin Tan, Zhangping Cai, Minyun Liu, Yasi Huang, Jinhui Hu^*, Wen-Hua Chen^* and Jia-Qiang Wu^*, Divergent synthesis of difluoromethylated indole-3-carbinols, bisindolylmethanes and indole-3-methanamines, Org. Biomol. Chem., 2023, 22, 90 - 94.

(15) Min Yuan, Jinhui Hu^*, Wen-Hua Chen^*, Synthesis of a Golgi-Targeting Fluorescent Probe for the Selective Detection of Chloride Anions, Org. Biomol. Chem., 2023, 21, 5732 - 5736.

(16) Li Chen, Yunfei Hu, Zhonghui Lu, Zeyin Lin, Lanqing Li, Jia-Qiang Wu, Zhi-Ling Yu, Chunye Wang, Wen-Hua Chen^*, Jinhui Hu^*, Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]Triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2, J. Med. Chem., 2023, 66, 15006 - 15024.

(17) Weiqiang Sun, Xueli Cui, Jing Qu, Xiaojia Cai, Jinhui Hu, Zhuang Xiong, Suqin Guo, Jun Xu^*, Wen-Hua Chen^*, Jia-Qiang Wu^*, Facile access to 2-hydroxy-2-substituted indole-3-ones via a copper-catalyzed oxidative cyclization of 2-arylethynylanilines, Chem. Commun., 2023, 59(47), 7228-7231.

(18) Xueli Cui, Jing Qu, Jianfeng Yi, Weiqiang Sun, Jinhui Hu, Suqin Guo, Jing-Wei Jin, Wen-Hua Chen^*, Wing-Leung Wong^*, Jia-Qiang Wu^*, Rh(III)-catalyzed redox-neutral C-H alkenylation of benzamides with gem-difluorohomoallylic silyl ethers via β-H elimination, Chem. Commun., 2023, 59, 3747-3750.

(19) Di Xiao, Li Lu, Bingwen Liang, Zhuang Xiong, Xuetao Xu^*, Wen-Hua Chen^*, Identification of 1,3,4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity, Eur. J. Med. Chem., 2023, 261, 115795.

(20) Xiaojia Cai, Jinyuan Xu, Xueli Cui, Jing Qu, Weiqiang Sun, Jinhui Hu, Shuwen Zhao, Wen-Hua Chen^*, Hongliang Li^*, Jia-Qiang Wu^*, Synthesis of difluoromethyl carbinols from the Friedel-Crafts reaction of electron-rich arenes with difluorovinyl arylsulfonates, Org. Chem. Front., 2022, 9, 6273 - 6280.

(21) Yunfei Hu, Li Chen, Canlin Zou, Jiangtao He, Luanqi Feng, Jia-Qiang Wu*, Wen-Hua Chen^*, Jinhui Hu^*, Access to 3-Amino-[1,2,4]-Triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization, Org. Lett., 2022, 24 (28), 5137 - 5142.

(22) Tao Zhang, Xiao-Qiao Hong, Hai-Tao Zhi, Jinhui Hu^*, Wen-Hua Chen^*, Synthesis and Mechanism of Biological Action of Morpholinyl-Bearing Arylsquaramides as Small-Molecule Lysosomal pH Modulators, RSC Adv., 2022, 12 (35), 22748 - 22759.

(23) Cheng-Jun Wu, Jia-Qiang Wu, Yunfei Hu, Suyun Pu, Yuying Lin, Zimai Zeng, Jinhui Hu^*, Wen-Hua Chen^*, Design, Synthesis and Biological Evaluation of Indole-based[1,2,4]Triazolo[4,3-a]Pyridine Derivatives as Novel Microtubule Polymerization Inhibitors, Eur. J. Med. Chem., 2021, 223, 113629.