基本情况
李英花，女，吉林省延吉市，群众。现任五邑大学药学与食品工程学院专任教师。
联系方式
地址：广东省江门市蓬江区东成村22号 五邑大学药学与食品工程学院
邮编：529020
邮箱：1332672570@qq.com
工作经历
2020年12月至今，五邑大学，药学与食品工程学院，硕士生导师
2014年12月至2020年11月，延边大学，农学院，硕士生导师
教育及学习经历
2011年3月-2014年8月，韩国忠北大学，农业生命环境科学院，畜牧学，博士
2006年9月-2009年2月，韩国忠北大学，农业生命环境科学院，畜牧学，硕士
2000年9月-2004年6月，延边大学农学院，学士
主要研究方向
1. 哺乳动物卵母细胞成熟及胚胎工程
2. 哺乳动物卵母细胞老化机制研究
发表学术论文
1. Chao-Rui Wang, Xiu-Wen Yuan, He-Wei Ji, Yong-Nan Xu, Ying-Hua Li*, Nam-Hyung Kim*. Chrysoeriol Improves the Early Development Potential of Porcine Oocytes by Maintaining Lipid Homeostasis and Improving Mitochondrial Function. Antioxidants (Basel). 2024 Jan 19;13(1):122
2. Sheng-Yan He, Rong-Ping Liu, Chao-Rui Wang, Xin-Qin Wang, Jing Wang, Yong- Nan Xu, Nam- Hyung Kim, Dong-Wook Han*, Ying- Hua Li*. Improving the developmental competences of porcine parthenogenetic embryos by Notoginsenoside R1- induced enhancement of mitochondrial activity and alleviation of proapoptotic events. Reprod Domest Anim. 2023 Sep 11
3. Chao-Rui Wang , He-Wei Ji, Sheng-Yan He, Rong-Ping Liu, Xin-Qin Wang, Jing Wang, Chu-Man Huang, Yong-Nan Xu, Ying-Hua Li* and Nam-Hyung Kim*. Chrysoeriol Improves In Vitro Porcine Embryo Development by Reducing Oxidative Stress and Autophagy. Vet Sci. 2023 Feb 10; 10(2):143. doi: 10.3390/vetsci10020143.
4. Sheng-Yan He, Rong-Ping Liu, Chao-Rui Wang, Xin-Qin Wang, Jing Wang, Yong- Nan Xu, Nam- Hyung Kim, Dong-Wook Han, Ying- Hua Li*. Improving the developmental competences of porcine parthenogenetic embryos by Notoginsenoside R1- induced enhancement of mitochondrial activity and alleviation of proapoptotic events. Reprod Domest Anim. 2023 Sep 11
5. Chao-Rui Wang , He-Wei Ji, Sheng-Yan He, Rong-Ping Liu, Xin-Qin Wang, Jing Wang, Chu-Man Huang, Yong-Nan Xu, Ying-Hua Li* and Nam-Hyung Kim*. Chrysoeriol Improves In Vitro Porcine Embryo Development by Reducing Oxidative Stress and Autophagy. Vet Sci. 2023 Feb 10; 10(2):143.
6. Rong-Ping Liu, Jing Wang, Xin-Qin Wang, Chao-Rui Wang, Sheng-Yan He, Yong-Nan Xu, Ying-Hua Li*, Nam-Hyung Kim. Xanthoangelol promotes early embryonic development of porcine embryos by relieving endoplasmic reticulum stress and enhancing mitochondrial function. Reprod Biomed Online. 2023 Aug;47(2):103211
7. Wen-Jie Jiang, Lin-Lin Hu, Yan-Ping Ren, Xiang Lu, Xiao-Qiong Luo, Ying-Hua Li *, Yong-Nan Xu*. Podophyllotoxin affects porcine oocyte maturation by inducing oxidative stress-mediated early apoptosis. Toxicon. 2020 Mar;176:15-20
8. Wenjie Jiang*, Yinghua Li*, Yuhan Zhao, Qingshan Gao, Qingguo Jin, Changguo Yan**, Yongnan Xu*. L-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes. Theriogenology. 2020 Feb; Vol143; 64-73.
9. Jeongwoo Kwon*, Ying-Hua Li*, Yu-Jin Jo, YoungJin Oh, Suk Namgoong, Nam-Hyung Kim. Inhibition of MEK1/2 and GSK3(2i system) affects blastocyst quality and early differentiation of porcine parthenotes. PeerJ. 2019 Jan 7; 6
10. Lin ZL*, Li YH*, Jin YX, Kim NH. A Maternal Transcription Factor, Junction Mediating and Regulatory Protein is Required for Preimplantation Development in the Mouse. Dev Reprod. 2019 Sep;23(3):285-295.
11. Ying-Hua Li*, Yong-Nan Xu, Zi-Li Lin, JeongWoo Kwon, Xiang-Shun Cui and Nam-Hyung Kim. Inhibition of the Arp2/3 complex impairs early embryo development of porcine parthernotes. Animal cell and systems. 2016 Vol. 20. NO 5. 253-259.
12. Li YH*, Kang H, Xu YN, Heo YT, Cui XS, Kim NH, Oh JS. Greatwall kinase is required for meiotic maturation in porcine oocytes. Biol Reprod。(2013) 89(3):53, 1–7
13. Xu YN*, Li YH*, Cui XS, Kim NH Hyperglycemia Influences Apoptosis and Autophagy in Porcine Parthenotes Developing In Vitro. Reprod Dev Biol. 2013 37(2): 65-73
14. Zhe-Long Jin, KangHe Xu, Jonghun Kim, Hao Guo, Xuerui Yao, Yong-Nan Xu, Ying-Hua Li, DongHee Ryu, Kee-Pyo Kim, Kwonho Hong, Yong-June Kim, Lin Wang, Qilong Cao, Kyun-Hwan Kim, Nam-Hyung Kim*, Dong Wook Han*. 3D hepatic organoid production from human pluripotent stem cells. Differentiation. 2023 Dec 12:135:100742.
15. Xuerui Yao, Ji Hyun Kang, Kee-Pyo Kim, Hyogeun Shin, Zhe-Long Jin, Hao Guo, Yong-Nan Xu, Ying-Hua Li, Sai Hali, Jeongwoo Kwon, Hyeonwoo La, Chanhyeok Park, Yong-June Kim, Lin Wang, Kwonho Hong, Qilong Cao, Il-Joo Cho, Dong Wook Han*, Nam-Hyung Kim*. Production of Highly Uniform Midbrain Organoids from Human Pluripotent Stem Cells. Stem Cells Int. 2023 Sep 29:2023:3320211.
16. Dong Wook Han, KangHe Xu, Zhe-Long Jin, Yong-Nan Xu, Ying-Hua Li, Lin Wang, Qilong Cao, Kee-Pyo Kim, DongHee Ryu, Kwonho Hong, Nam-Hyung Kim. Customized liver organoids as an advanced in vitro modeling and drug discovery platform for non-alcoholic fatty liver diseases.Int J Biol Sci. 2023;19(11):3595-3613.
17. Jing Wang , Xin-Qin Wang , Rong-Ping Liu , Ying-Hua Li , Xue-Rui Yao , Nam-Hyung Kim*, Yong-Nan Xu*. Melatonin Supplementation during In Vitro Maturation of Porcine Oocytes Alleviates Oxidative Stress and Endoplasmic Reticulum Stress Induced by Imidacloprid Exposure. Animals : an open access journal from MDPI, (2023).13(16), 2596.
18. Yong-Nan Xu, Guo-Bo Han, Ying-Hua Li, Chun-Hao Piao, Guan-Hao Li, Nam-Hyung Kim. Protective effect of onion peel extract on ageing mouse oocytes. Zygote. 2023 Oct;31(5):451-456
19. Jing Wang, Rong-Ping Liu, Xin-Qin Wang, Ying-Hua Li, Nam-Hyung Kim*, Yong-Nan Xu*. Dihydromyricetin supplementation during in vitro culture improves porcine oocyte developmental competence by regulating oxidative stress. JRD, 69: 10–17, 2023
20. Xin-Qin Wang, Rong-Ping Liu, Jing Wang, Dan Luo, Ying-Hua Li, Hao Jiang, Yong-Nan Xu*, Nam-Hyung Kim**. Wedelolactone facilitates the early development of parthenogenetically activated porcine embryos by reducing oxidative stress and inhibiting autophagy PeerJ. 2022 Jul 25;10
21. Wen-Jie Jiang, Wen Liu, Ying-Hua Li, Hao Jiang, Yong-Nan Xu*, Nam-Hyung Kim*. Citrinin impairs pig oocyte maturation by inducing oxidative stress and apoptosis. Toxicon. 2022 Jan 15;205:84-90.
22. Rong-Ping Liu, Xin-Qin Wang, Jing Wang, Luo Dan, Ying-Hua Li, Hao Jiang, Yong-Nan Xu*, Nam-Hyung Kim*. Oroxin A reduces oxidative stress, apoptosis, and autophagy and improves the developmental competence of porcine embryos in vitro. Reprod Domest Anim. 2022 Jul 2.
23. Xin-Qin Wang, Rong-Ping Liu, Jing Wang, Dan Luo, Ying-Hua Li, Hao Jiang, Yong-Nan Xu*, Nam-Hyung Kim**.Wedelolactone facilitates the early development of parthenogenetically activated porcine embryos by reducing oxidative stress and inhibiting autophagy PeerJ. 2022 Jul 25;10
申请及授权专利
1、黄当归醇在制备用于促进胚胎发育产品中的应用；李英花、何盛艳、刘容萍、金南衡、许永男；申请号：2023104235880；申请日期：2023.4.18
2、黄芪甲苷在制备促进囊胚形成和/或提高囊胚质量产品中的应用。李英花、王薪钦、金南衡、许永男、王晶、刘容萍；申请号：202310618037X；申请日期：2023.5.29
3、三七皂苷R1在制备促进体外胚胎发育产品中的应用；李英花、何盛艳、刘容萍、冀荷玮、许永男、金南衡；申请号：2023108613262；申请日期：2023.7.13
