基本情况

朱茂碧，女，海南人，中共党员，江门市二级人才。现任五邑大学药学与食品工程学院专任教师。主持五邑大学五邑大学高层次人才科研启动经费、省市级项目共计3项，在研总经费超过100万。参与国家自然科学基金面上项目、重点研发项目、广东省教育厅创新团队及重点领域专项等若干项。已发表SCI论文十多篇，其中第一作者及通讯作者文章5篇。目前依托华南生物医药大动物模型研究院及广东省医学大动物重点实验室开展研究工作，研究方向为利用干细胞及类器官技术研究妇产科相关疾病发生机制，生殖健康、基因编辑动物模型的建立等。

联系方式

地址：广东省江门市蓬江区东成村22号 五邑大学药学与食品工程学院

邮编：529020

邮箱：maobizhu@163.com

工作经历

2020年7月至今，五邑大学，药学与食品工程学院，硕士生导师

教育及学习经历

2016年4月-2020年3月 日本国立山梨大学，医学工学综合研究部，博士

2012年9月-2015年6月 厦门大学，医学院，硕士

2006年9月-2011年7月 厦门大学，医学院，学士

主要研究方向

利用干细胞及类器官技术研究妇产科相关疾病发生机制，生殖健康、基因编辑动物模型的建立等

发表学术论文

1. Chen, Y.; Zhang, S.; Sun, Y.; Zou, J.; Qiu, X.; Xi, H.; Xu, Y.; Li, Y.; Chen, B.; Fan, J.; Zhu, M. Bisphenol A impairs oocyte maturation by dysfunction of cumulus cells. Theriogenology 2025, 233, 139-146, doi:10.1016/j.theriogenology.2024.11.023. （通讯作者）

2. Wang, N.; Yang, H.; Chen, Y.; Wang, H.; Wang, C.; Fan, J.; Chen, Y.; Li, Y.; Zhu, M. Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress. Front Cell Dev Biol 2024, 12, 1520429, doi:10.3389/fcell.2024.1520429. （通讯作者）

3. Zhu, M.; Wang, N.; Wang, S.; Wang, Y.; Yang, X.; Fan, J.; Chen, Y. Effects of Follicular Fluid on Physiological Characteristics and Differentiation of Fallopian Tube Epithelial Cells Implicating for Ovarian Cancer Pathogenesis. Int. J. Mol. Sci. 2023, 24, 10154.

4. Zhu, M., S. Takeda, and T. Iwano, Natural Herbal Estrogen-Mimetics (Phytoestrogens) Promote the Differentiation of Fallopian Tube Epithelium into Multi-Ciliated Cells via Estrogen Receptor Beta. Molecules, 2021. 26(3).

5. Zhu, M.; Iwano, T.; Takeda, S. Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro—Stem Cell of Fallopian Epithelium. Biomolecules 2020, 10, 1270.

6. Zhu, M., Iwano, T., and Takeda, S. (2019). Estrogen and EGFR Pathways Regulate Notch Signaling in Opposing Directions for Multi-Ciliogenesis in the Fallopian Tube. Cells 2019, 8, 933.

7. Dai, S., Zhu, M., Wu, R., Lin, D., Huang, Z., Ren, L., Huang, S., Cheng, L., and Chen, Q. (2019). Lipoxin A4 Suppresses IL-1beta-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis. Reprod Sci, 1933719119828115. (Co-first author)

8. Wang, J.; Li, Y.-H.; Liu, R.-P.; Wang, X.-Q.; Zhu, M.-B.; Cui, X.-S.; Dai, Z.; Kim, N.-H.; Xu, Y.-N. Supplementation with Eupatilin during In Vitro Maturation Improves Porcine Oocyte Developmental Competence by Regulating Oxidative Stress and Endoplasmic Reticulum Stress. Animals 2024, 14, 449.

9. Chen, Y., X. Yang, S. Kitajima, L. Quan, Y. Wang, M. Zhu, E. Liu, L. Lai, H. Yan and J. Fan, Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. Front Cell Dev Biol, 2022. 10: p. 1097137.

10. Chen, Y., X. Yang, S. Kitajima, L. Quan, Y. Wang, M. Zhu, E. Liu, L. Lai, H. Yan and J. Fan, Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. Front Cell Dev Biol, 2022. 10: p. 1097137.

11. Huang, Q., Chen, Y., Chen, Q., Zhang, H., Lin, Y., Zhu, M., and Dong, S. (2017). Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine-inflammation interactions. Archives of toxicology 91, 1915-1924.

12. Chen, Y., Huang, Q., Chen, Q., Lin, Y., Sun, X., Zhang, H., Zhu, M., and Dong, S. (2015). The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells. Toxicology in vitro: an international journal published in association with BIBRA 29, 308-313.

13. Wu, R., Zhou, W., Chen, S., Shi, Y., Su, L., Zhu, M., and Chen, Q. (2014). Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway. British journal of pharmacology 171, 4927-4940.

14. Chen, S., Wu, R.F., Su, L., Zhou, W.D., Zhu, M.B., and Chen, Q.H. (2014). Lipoxin A4 regulates expression of the estrogen receptor and inhibits 17beta-estradiol induced p38 mitogen-activated protein kinase phosphorylation in human endometriotic stromal cells. Fertility and sterility 102, 264-271.

15. Shen, Y.T., Song, Y.Q., He, X.Q., Zhang, F., Huang, X., Liu, Y., Ding, L., Xu, L., Zhu, M.B., Hu, W.F., et al. (2014). Triphenyltin chloride induces spindle microtubule depolymerisation and inhibits meiotic maturation in mouse oocytes. Reprod Fertil Dev 26, 1084-1093.

16. Liu, Y., He, X.Q., Huang, X., Ding, L., Xu, L., Shen, Y.T., Zhang, F., Zhu, M.B., Xu, B.H., Qi, Z.Q., et al. (2013). Resveratrol protects mouse oocytes from methylglyoxal-induced oxidative damage. PLoS One 8, e77960.

参加学术会议及论文

(1) Estrogen promotes the fallopian tube epithelial multi-ciliogenesis through estrogen receptor β, Japan Society for Cell Biology,日本东京(会议报告)

(2) The Role of Estrogen and Notch Signal in Porcine Fallopian Tube Epithelium Differentiation,日本解剖学会年会,日本东京(会议报告)

(3) Suppression of Notch signal by estrogen and EGFR pathway facilitates motile ciliogenesis in fallopian tube epithelial cells,日本纤毛学会,日本山梨(会议报告)

(4) Estrogen regulates ciliogenesis through estrogen receptorβin porcine fallopian tube,日本解剖学会年会,日本长崎(会议报告)

申请及授权专利

1、一种体外猪来源的输卵管上皮细胞类组织培养方法，发明人：朱茂碧; 王娜; 王莎; 陈亚檞; 范江霖; 王瑶; 杨夏雯，申请号：202310019244.3，申请时间：2023年01月06日，授权单位：五邑大学，发明专利

2、一种促进输卵管上皮纤毛细胞形成的添加剂及其应用，发明人：朱茂碧,王莎,王娜,袭昊曈,张双,邹家伦,范江霖,陈亚檞，申请号：202310412768.9，申请日：2023 年04 月17 日，授权单位：五邑大学，发明专利

3、一种诱导原代输卵管上皮细胞定向分化为纤毛细胞的方法，发明人：朱茂碧,王莎,王娜,袭昊曈,张双,邹家伦,范江霖,陈亚檞，申请号：2023104133073，申请日：2023 年04 月17 日，授权单位：五邑大学，发明专利

获奖及荣誉

2017-2020中国留学基金委公派留学奖学金