基本情况
陈亚檞，男，山西大同人，中国共产党党员。现任五邑大学药学与食品工程学院专任教师。
联系方式
地址：广东省江门市蓬江区东成村22号五邑大学药学与食品工程学院
邮编：529020
邮箱：Yajie-Wuyi@yeah.net
工作经历
2020年7月至今，五邑大学，生物科技与大健康学院，硕士生导师
2019年11月至2020年6月，日本山梨大学医学部，助理教授
教育及学习经历
2015年10月-2019年9月，日本山梨大学医学部，博士
2012年9月-2015年7月，中国科学院城市环境研究生，硕士
2008年9月-2012年6月，华侨大学，本科
主要研究方向
高脂血症，动脉硬化，人源疾病大动物模型开发
发表学术论文
1.Chen YJ*, Waqar AB*, Nishijima K, Ning B, Kitajima S, Matsuhisa F, Chen L, Liu EQ, Zhang J, Chen YE, Liang JY and Fan JL: Macrophage-derived MMP-9 enhanced the vascular calcification and progression of atherosclerotic lesions in transgenic rabbits.J Cell Mol Med.2020;
2.Chen YJ*, Waqar AB*, Yan HZ, Wang YL, Liang JY, Fan JL. Renovascular hypertension aggravates atherosclerosis in cholesterol-fed rabbits.J Vasc Rea. 2019;56:28-38
3.Yuan TT, Zhong Y, Wang YG, Zhang T, Lu R, Zhou MY, Lu YY, Yan KN,Chen YJ, Hu ZH, Liang JY, Fan JL, Cheng Y. Generation of hyperlipidemic rabbit models using multiple sgrnas targeted crispr/cas9 gene editing system.Lipids Health Dis. 2019;18
4.Ning B*,Chen YJ, Waqar AB*, Yan HZ, Shiomi M, Zhang JF, Chen YE, Wang YL, Itabe H, Liang JY, Fan JL. Hypertension enhances advanced atherosclerosis and induces cardiac death in watanabe heritable hyperlipidemic rabbits.Am J Pathol. 2018;188:2936-2947
5.Fan JL,Chen YJ, Yan HZ, Niimi M, Wang YL, Liang JY. Principles and applications of rabbit models for atherosclerosis research.J Atheroscler Thromb. 2018;25:213-220
6.Fan JL,Chen YJ, Yan HZ, Liu BN, Wang YL, Zhang JF, Chen YE, Liu EQ, Liang JY. Genomic and transcriptomic analysis of hypercholesterolemic rabbits: Progress and perspectives.Int J Mol Sci. 2018;19
7.Lu R, Yuan TT, Wang YG, Zhang T, Yuan YG, Wu DJ, Zhou MY, He ZY, Lu YY,Chen YJ, Fan JL, Liang JY, Cheng Y. Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (ldlr) on exon 7.Ebiomedicine. 2018;36:29-38
8.Wang C, Nishijima K, Kitajima S, Niimi M, Yan HZ,Chen YJ, Ning B, Matsuhisa F, Liu EQ, Zhang JF, Chen YE, Fan JL. Increased hepatic expression of endothelial lipase inhibits cholesterol diet-induced hypercholesterolemia and atherosclerosis in transgenic rabbits.Arterioscl Throm Vas. 2017;37:1282-
9.Huang QS*,Chen YJ*, Lin LF, Liu YY, Chi YL, Lin Y, Ye GZ, Zhu HM, Dong SJ. Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of oryzias melastigma under environmentally relevant doses.Sci Total Environ. 2017;595:752-758
10.Huang QS*,Chen YJ*, Chen QH, Zhang HT, Lin Y, Zhu MB, Dong SJ. Dioxin-like rather than non-dioxin-like pcbs promote the development of endometriosis through stimulation of endocrine-inflammation interactions.Arch Toxicol. 2017;91:1915-1924
11.Ye GZ*,Chen YJ*, Wang HO*, Ye T, Lin Y, Huang QS, Chi YL, Dong SJ. Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol a and tetrachlorobisphenol a.Sci Rep-Uk. 2016;6
12.Ye T, Kang M, Huang QS, Fang C,Chen YJ, Liu LP, Dong SJ. Accumulation of di(2-ethylhexyl) phthalate causes endocrine-disruptive effects in marine medaka (oryzias melastigma) embryos.Environ Toxicol. 2016;31:116-127
13.Li S, Wang YN, Niimi MB, Ning B,Chen YJ, Kang DD, Waqar AB, Wang ZY, Yu Q, Liu EQ, Zhang JF, Shiomi M, Chen YE, Fan JL. Angiotensin ii destabilizes coronary plaques in watanabe heritable hyperlipidemic rabbits.Arterioscl Throm Vas. 2016;36:810-816
14.Chen YJ, Huang QS, Chen QH, Lin Y, Sun X, Zhang HT, Zhu MB, Dong SJ. The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells.Toxicol in Vitro. 2015;29:308-313
15.Huang QS*,Chen YJ*, Chi YL, Lin Y, Zhang HT, Fang C, Dong SJ. Immunotoxic effects of perfluorooctane sulfonate and di(2-ethylhexyl) phthalate on the marine fish oryzias melastigma.Fish Shellfish Immun. 2015;44:302-306
16.Lin Y, Min LL, Huang QS,Chen YJ*, Fang C, Sun X, Dong SJ. The combined effects of dehp and pcbs on phospholipase in the livers of mice.Environ Toxicol. 2015;30:197-204
17.Sun X, Lin Y, Huang QS, Shi JP, Qiu L, Kang M,Chen YJ, Fang C, Ye T, Dong SJ. Di(2-ethylhexyl) phthalate-induced apoptosis in rat ins-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection.J Cell Mol Med. 2015;19:581-594
18.Wei J, Sun X,Chen YJ, Li YY, Song LQ, Zhou Z, Xu B, Lin Y, Xu SQ. Perinatal exposure to bisphenol a exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet.J Endocrinol. 2014;222:313-325
19.Ye T, Kang M, Huang QS, Fang C,Chen YJ, Shen HQ, Dong SJ. Exposure to dehp and mehp from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (oryzias melastigma).Aquat Toxicol. 2014;146:115-126
20.Fang C, Huang Q, Ye T,Chen YJ, Liu L, Kang M, Lin Y, Shen HQ, Dong SJ. Embryonic exposure to pfos induces immunosuppression in the fish larvae of marine medaka.Ecotox Environ Safe. 2013;92:104-111
21.Huang QS, Fang C,Chen YJ, Wu X, Ye T, Lin Y, Dong SJ. Embryonic exposure to low concentration of bisphenol a affects the development of oryzias melastigma larvae.Environ Sci Pollut R. 2011;19:2506-2514
获奖及荣誉
1. Young Research Investigator Award for 27thJapan Atherosclerosis Society, July, 2019, Japan
2. The Kato Memorial Bioscience Grant for International Research Fellowship, April, 2019, Japan
3. Travel Grant for the 18thInternational Symposium on Atherosclerosis, ISA Scientific Program Committee, March, 2018, Canada
4. Special Scholarship for Oversea Students, Yamanashi University, 2015-2018, Japan
5.留学基金委设立的优秀自费留学生奖, 2017,中国
6. 研究生国家奖学金，2014，中国
