基本情况
邹庆剑,男,四川成都人。现任五邑大学药学与食品工程学院专任教师。
联系方式
地址:广东省江门市蓬江区东成村22号 五邑大学药学与食品工程学院
邮编:529020
邮箱:wyuchemzqj@126.com
工作经历
2018年5月至今,五邑大学,药学与食品工程学院,硕士生导师
2016年7月至2018年5月,天津天锐生物科技有限公司,研发总监
2013年7月至2018年6月,中国科学院广州生物医药与健康研究院,研究助理
教育及学习经历
2007年9月-2013年 6月,中国科学技术大学生命科学学院,硕士、博士
2002年9月-2006年6月,四川农业大学生命科学学院,学士
主要研究方向
基因治疗与干细胞治疗,基因编辑大动物模型构建与疾病治疗研究
发表学术论文
1. Liu, Y., Zhou, J., Lan, T., Zhou, X., Yang, Y., Li, C., Zhang, Q., Chen, M., Wei, S., Zheng, S., Cheng, L., Zheng, Y., Lai, L., and Zou, Q. (2022) Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites. Cell Discov 8, 28(通讯作者)【IF=38.1】
2. Zhou, J., Liu, Y., Wei, Y., Zheng, S., Gou, S., Chen, T., Yang, Y., Lan, T., Chen, M., Liao, Y., Zhang, Q., Tang, C., Liu, Y., Wu, Y., Peng, X., Gao, M., Wang, J., Zhang, K., Lai, L., and Zou, Q. (2022) Eliminating predictable DNA off-target effects of cytosine base editor by using dual guiders including sgRNA and TALE. Mol Ther (通讯作者)【IF=12.9】
3. Lan, T., Chen, H., Tang, C., Wei, Y., Liu, Y., Zhou, J., Zhuang, Z., Zhang, Q., Chen, M., Zhou, X., et al. (2023). Mini-PE, a prime editor with compact Cas9 and truncated reverse transcriptase. Mol Ther Nucleic Acids 33, 890-897. (通讯作者)【IF=10.8】
4. Chen, M., Wang, X., Li, C., Lan, T., Wei, Y., Tang, C., Zhou, X., Zhou, R., Rosa, A., Zheng, X., Ang, S., Zhang, K., Zou, Q., and Lai, L. (2022) Inducible motor neuron differentiation of human induced pluripotent stem cells in vivo. Cell Prolif, e13319(通讯作者)【IF=8.7】
5. Liu, Y., Yang, Y., Suo, Y., Li, C., Chen, M., Zheng, S., Li, H., Tang, C., Fan, N., Lan, T., Zhou, J., Li, Y., Wang, J., Chen, H., Zou, Q., and Lai, L. (2022) Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy. Mol Ther Methods Clin Dev 24, 332-341(通讯作者)【IF=6.7】
6. Lan, T., Zheng, Y., Suo, Y., Wei, Y., Shi, H., Yan, Q., Zhuang, Z., Chen, H., Zhang, Q., Fan, N., Zhao, Y., Ouyang, Z., Lai, C., Liu, Z., Zhou, J., Tang, C., Kim, N. H., Zou, Q., and Wang, X. (2022) Generation of pigs with humanized type II collagen by precise human COL2A1 gene knock-in. J Genet Genomics (通讯作者)【IF=5.8】
7. Zheng S, Zhong H, Zhou X, Chen M, Li W, Zi Y, Chi Y, Wang J, Zheng W, Zou Q, Lai L, Tang C. (2022). Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor. Cells. 【IF=7.5】(通讯作者)
8. Wu Y, Peng X, Ang S, Gao Y, Chi Y, Wang J, Tang C, Zhou X, Feng Y, Zhang K, Zou Q, Chen M. (2023). Bcl-xL Promotes the Survival of Motor Neurons Derived from Neural Stem Cells. Biology (Basel). 【IF=5.1】(通讯作者)
9. Zhou J, Yan Q, Tang C, Liao Y, Zhang Q, Wang X, Zhou X, Lai L, Zou Q. Development of a rabbit model of Wiskott-Aldrich syndrome. FASEB J. 2021 Feb;35(2):e21226 (通讯作者)【IF=5.8】
10. Cheng, L., Zhou, X., Zheng, Y., Tang, C., Liu, Y., Zheng, S., Liu, Y., Zhou, J., Li, C., Chen, M., Lai, L., and Zou, Q. (2021) Simple and Rapid Assembly of TALE Modules Based on the Degeneracy of the Codons and Trimer Repeats. Genes (Basel) 12(通讯作者)【IF=4.5】
11. Li L, Meng H, Zhang J, Liu Y, Zou Q, Gao Y, Yang H, Lai L. A tunable, rapid, and precise drug control of protein expression by combining transcriptional and post-translational regulation systems. J Genet Genomics. 2020 Nov 20;47(11):705-712. (通讯作者)【IF=5.1】
12. Zou, Q., Wang, X., Liu, Y., Ouyang, Z., Long, H., Wei, S., Xin, J., Zhao, B., Lai, S., Shen, J., Ni, Q., Yang, H., Zhong, H., Li, L., Hu, M., Zhang, Q., Zhou, Z., He, J., Yan, Q., Fan, N., Zhao, Y., Liu, Z., Guo, L., Huang, J., Zhang, G., Ying, J., Lai, L., and Gao, X. (2015) Generation of gene-target dogs using CRISPR/Cas9 system. Journal of molecular cell biology 7, 580-583(第一作者)【IF=6.7】
13. Wei, S., Zou, Q., Lai, S., Zhang, Q., Li, L., Yan, Q., Zhou, X., Zhong, H., and Lai, L. (2016) Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators. Scientific reports 6, 19648(通讯作者+第一作者)【IF=5.5】
14. Zou, Q., Yan, Q., Zhong, J., Wang, K., Sun, H., Yi, X., and Lai, L. (2014) Direct conversion of human fibroblasts into neuronal restricted progenitors. The Journal of biological chemistry 289, 5250-5260(第一作者)【IF=4.6】
参加学术会议及论文
……
申请及授权专利
1. 邹庆剑;程令印;郑雨龄;郑淑文;刘玉;周小青;唐成程;陈敏;赖良学;一种基于密码子简并性的快速TALE表达载体构建方法,2021-07-01,申请号: 202110746218.1
2. 钟慧霖;邹清雁;刘海霞;邹庆剑;杜少茵;梁海燕;吴志君;叶俊杰;一种嵌合抗原受体、嵌合抗原受体脐血有核细胞及应用,2020-12-04,申请号:202011411287.9
3. 唐成程;邹庆剑;周小青;陈敏;赖良学;用于猪MBP基因敲除的sgRNA组合物及用途,2020-06-01,申请号:202010488188.4
4. 陈敏;王霞;周继曾;陈晃耀;魏愈慧;蓝婷;邹庆剑;周小青;唐成程;张焜;周仁平;赖良学;可定向诱导的、抗凋亡的多能干细胞及其制备方法与应用,2019-10-22,申请号:201911005295.0
5. 周小青;赖良学;邹庆剑;唐成程;一种提高猪胚胎基因修饰纯合子的方法,2020-02-18,申请号:202010100231.5
6. 唐成程;郑淑文;邹庆剑;郑雨龄;李万胜;周小青;资崯;陈敏;赖良学;识别猪PERV基因的sgRNA及其编码DNA和应用,2022-01-29,申请号:202210110465.7
7. 周小青;唐成程;邹庆剑;陈敏;赖良学; 一种可用于异种器官移植的供体猪的构建方法 -2020-08-21,申请号:202010851140.5
8. 赖良学;刘洋;邹庆剑;周继曾;周小青;杨洋;李川;刘玉;程令印;郑雨龄;一种单碱基编辑工具TaC9-ABE及其应用,2021-08-20,申请号: 202110963044.4