基本情况
刘君羊，男，中共党员。五邑大学药学与食品工程学院副教授，硕士研究生导师。
个人简介及研究方向
主要从事活性（海洋）天然产物的全合成、结构修饰和构效关系研究，完成了包括甾体、萜类、大环内脂类、环肽类等超过18个活性天然产物的全合成。历年来主持国家自然科学基金面上基金、青年基金，国家重点实验室开放课题项目、广东省教育厅学科重点提升项目，深圳市面上项目等9项。目前在J. Am. Chem. Soc.、Chem、Green Syn. Catal.、Org. Lett.、Chinese J. Chem.、Org. Chem. Front.、Chem. Commun.、J. Org. Chem.、Nature Chemistry等国际刊物上发表研究论文38篇，其中以（共同）第一作者/（共同）通讯作者发表28篇，申请专利6项，授权2项。目前是广东省药理学会海洋药物药理专业委员会委员，国自然科学基金、广东省基础与应用基础研究基金项目评审专家，广东省高层次人才评审专家，Chemical Science, RSC Advances, Marine Drugs等杂志审稿人。
联系方式
地址：广东省江门市蓬江区东成村22号五邑大学药学与食品工程学院
邮编：529020
e-mail：liujy@wyu.edu.cn
工作经历
2022.02至今 ，五邑大学，药学与食品工程学院，副教授，硕士生导师；
2017.12至2022.02，南方科技大学，高级研究学者、研究助理教授/研究副教授；2012.10至2017.11，北京大学、香港理工大学、南方科技大学，博士后/访学；
教育及学习经历
2006.09-2012.01 北京大学 博士
2001.09-2005.07 南昌大学 本科
科研项目
1. 国家自然科学基金，面上项目，2024.01-2027.12，主持；
2. 国家自然科学基金，青年基金项目，2017.01-2019.12，主持；
3. 广东省教育厅重点建设学科科研能力提升项目，2022.1-2024.12，主持；
4. 国家重点实验室，开放课题项目，2023.1-2024.12，主持；
5. 深圳市科创委，面上项目，2020.06-2023.6，主持；
发表学术论文
1. Liu, Junyang; Wu, Jianlei; Fan, Jian-Hong; Yan, Xin; Mei, Guangjian; Li, Chuang-Chuang, Asymmetric Total Synthesis of Cyclocitrinol. J. Am. Chem. Soc. 2018, 140, (16), 5365-5369.
2. Liu, Xin#; Liu, Junyang#; Wu, Jianlei; Huang, Guocheng; Liang, Rong; Chung, Lung Wa; Li, Chuang-Chuang*, Asymmetric Total Synthesis of Cerorubenic Acid-III. J. Am. Chem. Soc. 2019, 141, (7), 2872-2877.
3. Liu, Junyang#; Liu, Xin#; Wu, Jianlei; Li, Chuang-Chuang*, Total Synthesis of Natural Products Containing a Bridgehead Double Bond. Chem 2020, 6, (3), 579-615.
4. Chen, Louxi; Zhang, Chao-Han; Liu, Junyang*; Sun, Jianwei*; Li, Chuang-Chuang*, Asymmetric Synthesis of the Tetracyclic Core of Venezuelaene B. Org. Lett. 2025, 27, (14), 3517-3520.
5. Chen, Louxi; Zhang, Chao-Han; Liu, Junyang*; Li, Chuang-Chuang*, Asymmetric synthesis of venezuelaene's core with a trans-fused [5-5] ring system. Chem. Commun. 2025, 61, (58), 10823-10826.
6. Feng, Jiaxuan; Liu, Junyang*; Ye, Tao, Total Synthesis, Stereochemical Assignment, and Structural Revision of HA 23. Org. Lett. 2025, 27, (33), 9299-9303.
7. Peng, Wenquan#; Han, Feipeng#; Liu, Junyang#; Wang, Chenqi; Minami, Atsushi; Oikawa, Hideaki; Guo, Yian; Ye, Tao, Thermolides D and E: Total Synthesis and Stereochemical Revision. Org. Lett. 2025, 27, (30), 8183-8188.
8. Wang, Chenqi; Liu, Junyang*; Ye, Tao*, Synergy of prediction rule and total synthesis in solving the stereochemical puzzle of eucalactam B. Org. Chem. Front. 2025, 12, (1), 70-75.
9. Jiang, Yangyang; Liu, Junyang*; Ye, Tao*, Total synthesis and stereochemical assignment of cubensci acid. Org. Chem. Front. 2025, 12, 4525–4529
10. Long, Xiong-En; Xing, Hailiang; He, Yixin; Meng, Xuanli; Ma, Yanling; Liu, Chang; Cao, Xi; Nan, Huiru; Cheng, Min-Jing*; Yan, Jia-Lei*; Liu, Junyang*, Total synthesis and biological evaluation of Koshidacin B, TAN-1746, and Ac-TAN-1746. BMC Chemistry 2025, 19, 213.
11. Liu, Haoyang; Xing, Hailiang; Yu, Peilan; Wang, Yanjie; Yan, Jia-Lei; Liu, Junyang*; Wang, Min*, Base-Controlled Synthesis of Heteroatom-Embedded 9-Membered Cycloalkynes and 6-Membered Sultams through Copper-Catalyzed Cyclization. J. Org. Chem. 2025, 90, (2), 984-993.
12. Nan, Huiru; Long, Xiong-En; He, Jianfei; Xing, Hailiang; Cheng, Min-Jing; Peng, Jin-Bao; Ye, Tao*; Yan, Jia-Lei*; Liu, Junyang*, Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D. Mar. Drugs 2025, 23, (3), 99.
13. Gu, Chen-Chen; Long, Xiong-En; Chen, Xiuping; Liu, Junyang*; Li, Chuang-Chuang*, Recent Natural Product Total Syntheses Involving Cycloadditions of Allenes. Chin. J. Chem. 2025, 43, (9), 1059-1077.
14. Liu, Junyang; Chen, Kai; Guo, Yian; Chen, Ying; Ye, Tao*, Total Synthesis of Rhizopodin Enabled by a Late-Stage Oxazole Ring Formation Strategy. Org. Lett. 2024, 26, (41), 8928-8933.
15. Yan, Jia-Lei; Nan, Huiru; Fang, Xiaoyu; Long, Xiong-En; Jiang, Yu; Liu, Junyang*, The isolation, bioactivity, and synthesis of natural products from Litsea verticillate with anti-HIV activities. Front. Pharmacol. 2024, 15, 1477878.
16. Xiao, Yi#; Liu, Junyang#; Jiang, Yangyang; Guo, Yian; Ye, Tao*, Total Syntheses and Stereochemical Assignment of Acremolides A and B. Molecules 2024, 29, (15), 3599.
17. Hou, Bao-Long*; Liu, Junyang*; Qiao, Chuang*; Li, Chuang-Chuang*, Total synthesis of natural products containing bicyclo[n.2.2] ring systems. Tetrahedron Lett. 2024, 135, 154871.
18. He, Yujie; Chen, Jintao; Jiang, Yu; Fang, Xiaoyu; Liu, Junyang*; Yan, Jia-Lei*, N-Heterocyclic Carbene Catalyzed Reactions Involving Acetylenic Breslow and/or Acylazolium as Key Intermediates. Chem. Rec. 2024, 24, (12), e202400165.
19. Liu, Junyang#; Tang, Shoubin#; Yan, Jia-Lei; Ye, Tao*, Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate. Molecules 2023, 28, (2), 780.
20. Liu, Junyang; Chen, Hang; Wang, Min; He, Wangjin; Yan, Jia-Lei*, Organocatalytic asymmetric synthesis of P-stereogenic molecules. Front. Chem. 2023, 11.
21. Hui, Chunngai#, *; Wang, Zhuo#; Xie, Yusheng*; Liu, Junyang*, Contemporary synthesis of bioactive cyclobutane natural products. Green Synth. Catal. 2023, 4, (1), 1-6.
22. Liu, Junyang*; Chen, Ying; Luesch, Hendrik; Ye, Tao*, Total Synthesis of des-Thiomethyllooekeyolide A. Org. Lett. 2022, 24, (40), 7260-7264.
23. Wu, Jianlei#; Liu, Junyang#, *; Fan, Jian-Hong; Xie, Zhi-Dong; Qin, Hukun; Li, Chuang-Chuang*, Evolution of Routes for Asymmetric Total Synthesis of Cyclocitrinol Enabled by Type II [5+2] Cycloaddition†. Chin. J. Chem. 2021, 39, (5), 1247-1254.
24. Liu, Xin#; Liu, Junyang#; Wu, Jianlei; Li, Chuang-Chuang*, Enantioselective Total Synthesis of Cerorubenic Acid-III via Type II [5+2] Cycloaddition Reaction. J. Org. Chem. 2021, 86, (16), 11125-11139.
25. Liu, Xin#; Liu, Junyang#; Zhao, Jing; Li, Shaoping; Li, Chuang-Chuang*, Toward the Total Synthesis of Eurifoloid A. Org. Lett. 2017, 19, (10), 2742-2745.
26. Liu, Junyang; Wang, Lei; Zhang, Juefei; Xu, Zhengshuang*; Ye, Tao*, The total synthesis and stereochemical assignment of scytonemin A. Chem. Commun. 2016, 52, (5), 1002-1005.
27. Song, Liankai#; Liu, Junyang#; Gui, Honggang; Hui, Chunngai; Zhou, Jingjing; Guo, Yian; Zhang, Pengpeng; Xu, Zhengshuang*; Ye, Tao*, Synthesis of the Macrocyclic Core of Rhizopodin. Chem. - Asian J. 2013, 8, (12), 2955-2959.
28. Liu, Junyang; Ma, Xiao; Liu, Yuqing; Wang, Zhuo; Kwong, Shuqin; Ren, Qi; Tang, Shoubin; Meng, Yi; Xu, Zhengshuang*; Ye, Tao*, Total Synthesis and Stereochemical Revision of Burkholdac A. Synlett 2012, 23, (05), 783-787.
申请及授权专利
1. 刘君羊，南慧茹，龙雄恩，邢海亮，何健飞，马艳玲，一种环肽 Lagunamide D 的制备方法，2024-12-30，中国，2024119701774。
2. 刘君羊，龙雄恩，南慧茹，邢海亮，刘昊洋，一种四环肽中间体化合物及其制备方法和应用，2024-09-06，中国，202411250389.5。
3. 刘君羊，刘昊洋，邢海亮，王敏，一种六元环磺酰胺类化合物的制备方法，2024-07-12，中国，202410937674（公开）。
4. 刘君羊，景显彤，陈娄曦，李闯创，虎皮楠生物碱骨架的合成方法，2022-02-11，中国，CN116621868A（公开）。
5. 刘君羊，南慧茹，龙雄恩，闫加磊，一种化合物及其合成方法与在肌动蛋白稳定剂的合成方法中的应用，2023-12-04，中国，ZL202311645681.2（授权）。
6. 刘君羊，吴建磊，范建红，李闯创，甾体化合物的制备方法，2018-03-13，中国，ZL201810205745.X（授权）。
